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The organism requires minimal set of functional genes for its survival. Bateman A, Birney E, Cerruti L (2002).‖The Pfam Protein Families Database‖. Two kinds of improved evolution rules are proposed to replace the rule in regular cellular genetic algorithm, in which null cells are considered to the foods of individuals in population and the maximum of living individuals in cellular space is limited by their food.

This infectious disease results in Leprosy reactions that cause irreversible nerve damage and disabilities. Black PN, Zhang Q, Weimar JD, Di Russo CC (1997) Mutational analysis of a fatty Acyl-coenzyme A Synthetase signature motif identifies seven amino acid residues that modulate fatty acid substrate specificity. In: Proceedings of the ACM/IEEE Conference on Supercomputing (SC06), Nov 11–17, Florida. Chemotherapy of leprosy for control programs- report of WHO study (2004). In this paper, we advanced two kinds of cellular genetic algorithms inspired by the density dependence scheme in ecological system to solving dynamic optimization problems.

Adhinarayanan, Maheswarapu Sydulu "Particle Swarm Optimisation for Economic Dispatch with Cubic Fuel Cost Function", TENCON 2006, IEEE region conference. Acyl Co A Synthetase is an enzyme that participates in fatty acid biosynthesis. The performance of proposed cellular genetic algorithms is examined under three dynamic optimization problems with different change severities.

Most of the genes are involved in biosynthetic and metabolic pathways, so the product of these genes can be aimed for the novel drug target. Transmembrane movement of exogenous long-chain fatty acids: proteins, enzymes, and vectorial esterification. Moreover, in the second proposed rule, the competition scheme of the best individuals within the neighborhoods of one individual is also introduced.

Gao Yue-lin , Duan Yu-hong "A New Particle Swarm Optimization Algorithm with Random Inertia Weight and Evolution Strategy" International Conference on Computational Intelligence and Security Workshops 2007. Guimin Chen, Xinbo Huang, Jianyuan Jia and Zhengfeng Min " Natural Exponential Inertia Weight Strategy in Particle Swarm Optimization" 6th World Confress on Intelligent Control and Automation, June 21 - 23, 2006, Dalian, China. Jong-Bae Park, Yun-Won Jeong, Hyun Houng Kim and Joong-Rin Shin "An Improved Particle Swarm Optimization for Economic Dispatch with Valve-Point Effect" International Journal of Innovations in Energy Systems and Power, Vol. Therefore by emphasizing this protein as a drug target can help in the identification of novel drugs to cure leprosy. Black PN, Zhang Q, Weimar JD, Di Russo CC (1997): Mutational analysis of a fatty Acyl-coenzyme A Synthetase signature motif identifies seven amino acid residues that modulate fatty acid substrate specificity. Key words: cellular genetic algorithm, dynamic optimization, density dependence scheme Reference [1] R.

The proposed system is a four ports hydraulic cylinder fitted with a novel flow control valve. Goldenberg, "Design of a new high performance electrohydraulic actuator," in Proceedings of The International Conference on Advanced Intelligent Mechatronics, IEEE/ASME,, 1999, pp. Key words: docking, homology modeling, leprosy, M.leprae, molecular, molecular dynamics, ramachandran plot. Therefore identification of the novel drug target and potent drug can be helpful in better prevention of the disease. Alter et.al, (2008) Leprosy as a genetic model for susceptibility to common infectious disease, Hum Genet 2. (1999)Health Policy and Planning; 14(2): 89-102, Oxford University Press. The bacteria have developed resistance against many of the drugs available in the market. Halgamuge "Self-Organizing Hierarchical Particle Swarm Optimizer With Time Varying Acceleration Coefficients" IEEE Trans. A well organized research comprising of analogue based drug design and molecular dynamics plays a major role in obtaining the lead molecules. Black PN, Di Russo CC, Metzger AK, Heimert TL (1992): Cloning, sequencing, and expression of the fad D gene of Escherichia coli encoding Acyl coenzyme A Synthetase.

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