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A global loss of connectivity was observed in more disabled patients and correlated with accumulation of disability.

Cross-sectional studies support the observation that functional reorganization in MS is complex and leads to different patterns of activation and deactivation related to disability.

In conclusion, PPMS seems to induce a loss of structural connections between important brain regions.

Thus, we cannot conclude about the role of subcortical gray matter or the cerebellum in the rich-club topology.

Hilgetag), and Department of Diagnostic and Interventional Neuroradiology (S. Concerning the mechanisms behind our observations, our interpretations remain hypothetical, as we did not investigate longitudinal changes.

Moreover, we could not apply model selection in multivariate statistics to determine the specificity of rich-club alterations for disability in comparison with other MRI measurements.

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